The European UNLOOC (Unlocking the data content of Organ-on-Chips) project aims to address the challenges of animal testing in drug development by demonstrating how innovative methods based on Organ-on-a-Chip (OOC) technology can facilitate the creation of more effective treatments while eliminating the need for animal subjects. The OOC technology developed in this framework will not only enable controlled drug testing but also model the pathophysiology of diseases.
HEPIA contributes, in collaboration with Microfluidic ChipShop, Alvtradeolix and CSEM, by developing a Lung-on-Chip model focused on pulmonary epithelial cells and working on a measurement platform consisting of a bio-impedance device structured around two electronic carts: one integrating a measurement head with frequency spectrum analyzer chips TEEROC, enabling the recording of transepithelial electrical resistance (TEER) of cells as a function of signal frequency, and the other consisting of an interface board equipped with porous and flexible electrodes, microfabricated in a cleanroom, allowing TEER measurement at the air-liquid interface. These data will then be used to feed into an AI-based analysis system.
TEEROC - a bio-impedance measuring user interface
Picture: TEEROC - a bio-impedance measuring electronic board
Project partner(s)
Project leader - team
Adrien Roux
(HEPIA),
Marc Heuschkel
(HEPIA),
Shaginth Sivakumar
(HEPIA),
Nicola Giandomenico
(HEPIA),
Harley Stoeckli
(HEPIA)
