Bactericidal nanoblades

A proof-of-concept approach for bimodal chemo-mechanical eradication of persistent biofilms

Biofilms provide bacteria with a protective mechanical shield and a highly favorable environment for their growth and proliferation on many surfaces. The eradication of bacterial biofilms has become a major challenge in healthcare, the food industry, water supply, and ventilation and air treatment systems. Therefore, it is essential to find effective solutions to eliminate persistent biofilms.

Supported by the Swiss National Science Foundation (SNSF), this project aims to validate a new concept: bactericidal nanoblades, capable of eliminating biofilms through a combined chemo-mechanical action.

To achieve this:

• Magnetic rods, fabricated in the laboratory, are set in motion by an external magnetic field. They act like true micro- and nano-robots, mechanically destroying the biofilm structure through rotational motion.
• At the same time, these particles release silver ions, creating a powerful broad-spectrum antimicrobial environment.

This dual synergistic action will be tested on different types of biofilms and surfaces, including those that pose serious challenges in medical and food industry contexts.

Thanks to this innovative and interdisciplinary approach, this project could represent a groundbreaking new strategy to effectively combat biofilms and improve sanitary safety in many fields.