Jean-Noël Hyacinthe

Professeur HES associé

Filière Technicien en radiologie médicale

Téléphone de service : +41 22 388 56 00

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Profil

Projets Ra&D

SUBREAM

Smart And Ultrafast Breast MR Imaging For Cancer Detection

(2022 - En cours)

Belinda Lokaj, Jérôme Schmid, Jean-Noël Hyacinthe, Christophe Chênes, Christian Lovis (Hôpitaux Universitaires de Genève, Service des sciences de l’information médicale), Karen Kinkel (Réseau hospitalier neuchâtelois, Département d'imagerie médicale)

Thématique(s) et méthode(s): Vieillir en bonne santé, Santé des femmes et de la famille, Recherche clinique, Technologie de la santé

Cibler l’AVC avec l’IRM hyperpolarisée

(2017 - En cours)

Jean-Noël Hyacinthe Lorenz Hirt (CHUV, Lausanne)

Thématique(s) et méthode(s): Vieillir en bonne santé, Pratiques professionnelles, Recherche clinique, Technologie de la santé

Novel theranostic approaches for stroke based on hyperpolarized Magnetic Resonance Imaging

(2017 - 2021)

Jean-Noël Hyacinthe, Elise Vinckenbosch, Thanh Phong Kevin Lê

Thématique(s) et méthode(s): Vieillir en bonne santé, Recherche clinique, Technologie de la santé

Theranostic approaches for stroke based on hyperpolarized magnetic resonance imaging

(2016 - 2016)

Jean-Noël Hyacinthe

Thématique(s) et méthode(s): Vieillir en bonne santé, Recherche clinique, Technologie de la santé

Cascade-AMplified UltraSound focal ablation (CAMUS)

(2015 - 2015)

Jean-Noël Hyacinthe

Thématique(s) et méthode(s): Pratiques professionnelles, Technologie de la santé

Publications

How to improve the efficiency of a traditional dissolution dynamic nuclear polarization (dDNP) apparatus: Design and performance of a fluid path compatible dDNP/LOD-ESR probe

Lê, T. P., Hyacinthe, J.-N., Capozzi, A. (2022). Journal of Magnetic Resonance, 338(article 107197), 1-10.

https://doi.org/10.1016/j.jmr.2022.107197

Hyperpolarization of 129Xe gas via dissolution DNP : beneficial tips and tricks

Wiström, E. L. , Capozzi, A., Lê, T. P., Gruetter, R., Hyacinthe, J. N. (2022). ISMRM

https://www.ismrm.org/22m/

Triple multinuclear probe: expanding the throughput and versatility of a dDNP polarizer

Lê, T. P., Wiström, E. L., Hyacinthe, J. N., Capozzi, A. (2022). ISMRM

https://www.ismrm.org/22m/

Hyperpolarize 129XE gas via dissolution DNP : tips and tricks

Capozzi, A., Lê, T. P., Hyacinthe, J.-N. (2021). International Hyperpolarization Conference

http://hyp-lyon.org/en

DNP polarizing agents in preclinical HP MRS: influence in the context of transient ischemic stroke

Lê, T. P., Buscemi, L., Lepore, M., Hirt, L., Hyacinthe, J.-N., Mishkovsky, M. (2021). ISMRM

https://www.ismrm.org/21m/

Hyperpolarized in-vivo metabolic imaging at 14.1T: dDNP cryogenic insert redesign and implementation

Lê, T. P., Capozzi, A., Hyacinthe, J.-N. (2021). ISMRM

https://www.ismrm.org/21m/

Retrofit of a wet DNP polarizer with a custom fluid path : better polarization and cryogenic performances

Lê, T. P., Hyacinthe, J.-N., Capozzi, A. (2021). International Hyperpolarization Conference

http://hyp-lyon.org/en

Evaluating the potential of hyperpolarised [1-13C] L-lactate as a neuroprotectant metabolic biosensor for stroke

Hyacinthe, J.-N., Buscemi, L., Lê, T. P., Lepore, M., Hirt, L., Mor, M. (2020). Scientific Reports, 10, 1-11.

https://doi.org/10.1038/s41598-020-62319-x

Micron-sized PFOB liquid core droplets stabilized with tailored-made perfluorinated surfactants as a new class of endovascular sono-sensitizers for focused ultrasound thermotherapy

Desgranges, S., Lorton, O., Gui-Levy, L., Guillemin, P., Celicanin, Z., Hyacinthe, J.-N., Breguet, R., Crowe, L.A., Becker, C.D., Soulié, M., Taulier, N., Contino-Pépin, C., Salomir, R. (2019). Journal of Materials Chemistry B, 7 (6)

https://doi.org/10.1039/c8tb01491d

Molecular oxygen loading in candidate theranostic droplets stabilized with biocompatible fluorinated surfactants: Particle size effect and application to in situ(19)F MRI mapping of oxygen partial pressure

Lorton, O., Hyacinthe, J. N., Desgranges, S., Gui, L., Klauser, A., Celicanin, Z., Crowe, L. A., Lazeyras, F., Allemann, E., Taulier, N., Contino-Pepin, C., Salomir, R. (2018). Journal of Magnetic Resonance , 295, 27-37.

https://doi.org/10.1016/j.jmr.2018.07.019

Hybrid ultrasound-MR guided HIFU treatment method with 3D motion compensation

Celicanin, Z., Manasseh, G., Petrusca, L., Scheffler, K., Auboiroux, V., Crowe, L. A., Hyacinthe, J. N., Natsuaki, Y., Santini, F., Becker, C. D., Terraz, S., Bieri, O., Salomir, R. (2018). Magnetic Resonance in Medicine , 79 (5), 2511-2523.

https://doi.org/10.1002/mrm.26897

In vivo pink-beam imaging and fast alignment procedure for rat brain tumor radiation therapy

Nemoz, C., Kibleur, A., Hyacinthe, J. N., Berruyer, G., Brochard, T., Brauer-Krisch, E., Le Duc, G., Brun, E., Elleaume, H., Serduc, R. (2016). Journal of Synchrotron Radiation, 23 (1), 339-43.

https://doi.org/10.1107/S1600577515018561

Correcting surface coil excitation inhomogeneities in single-shot SPEN MRI

Schmidt, R., Mishkovsky, M., Hyacinthe, J. N., Kunz, N., Gruetter, R., Comment, A., Frydman, L. (2015). Journal of Magnetic Resonance , 259, 199-206.

https://doi.org/10.1016/j.jmr.2015.08.018

Photoinduced nonpersistent radicals as polarizing agents for X-nuclei dissolution dynamic nuclear polarization

Capozzi, A., Hyacinthe, J.-N., Cheng, T., Eichhorn, T. R., Boero, G., Roussel, C., van der Klink, J. J, Comment, A. (2015). The Journal of Physical Chemistry C, 119 (39), 22632-22639.

https://doi.org/10.1021/acs.jpcc.5b07315

Beyond spin exchange optical pumping: hyperpolarization of 129Xe via sublimation dynamic nuclear polarization

Hyacinthe, J.N., Capozzi, A., Comment, A. (2015). Hyperpolarized Xenon-129 Magnetic Resonance (Concepts, Production, Techniques and Applications)

https://doi.org/10.1039/9781782628378-00442

Optimal glass-forming solvent brings sublimation dynamic nuclear polarization to129Xe Hyperpolarization biomedical imaging standards

Capozzi, A., Roussel, C., Comment, A., Hyacinthe, J. N. (2015). The Journal of Physical Chemistry C, 119 (9), 5020-5025.

http://dx.doi.org/10.1021/jp5124053

Nouveaux horizons pour l’imagerie moléculaire

Hyacinthe, J.N. (2014). Planète Santé

https://www.planetesante.ch/Magazine/Cancer/Cancer-de-la-prostate/Nouveaux-horizons-pour-l-imagerie-moleculaire

Hyperpolarization without persistent radicals for in vivo real-time metabolic imaging

Eichhorn, T. R., Takado, Y., Salameh, N., Capozzi, A., Cheng, T., Hyacinthe, J.N., Mishkovsky, M., Roussel, C., Comment, A. (2013). Proceedings of the National Academy of Sciences, 110 (45), 18064-18069.

https://doi.org/10.1073/pnas.1314928110

Pulsatile blood flow in human bone assessed by laser-Doppler flowmetry and the interpretation of photoplethysmographic signals

Binzoni, T., Tchernin, D., Hyacinthe, J.-N., Van De Ville, D., Richiardi, J. (2013). Physiological Measurement, 34 (3), N25-40.

http://stacks.iop.org/0967-3334/34/i=3/a=N25?key=crossref.17f52a372824595c2388332807e870da

Haemodynamic responses to temperature changes of human skeletal muscle studied by laser-Doppler flowmetry

Binzoni, T., Tchernin, D., Richiardi, J., Van De Ville, D., Hyacinthe, J.N. (2012). Physiological Measurement, 33 (7), 1181-1197.

http://stacks.iop.org/0967-3334/33/i=7/a=1181?key=crossref.d0cbe11047ab103495d7fcecff248d7b

High time-resolved cardiac functional imaging using temporal regularization for small animal on a clinical 3T scanner

Delattre, B. M. A., Van De Ville, D., Braunersreuther, V., Pellieux, C., Hyacinthe, J.N., Lerch, R., Mach, F., Vallee, J.P. (2012). IEEE Transactions on Biomedical Engineering, 59 (4), 929-935.

http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=6068237

Manganese kinetics demonstrated double contrast in acute but not in chronic infarction in a mouse model of myocardial occlusion reperfusion

Delattre, B. M. A., Braunersreuther, V., Gardier, S., Hyacinthe, J.N., Crowe, L. A., Mach, F., Vallee, J.P. (2012). NMR in Biomedicine, 25 (4), 489-497.

http://doi.wiley.com/10.1002/nbm.1759

Matching between regional coronary vasodilator capacity and corresponding circumferential strain in individuals with normal and increasing body weight

Vincenti, G. M., Ambrosio, G., Hyacinthe, J.N., Quercioli, A., Seimbille, Y., Mach, F., Ratib, O., Vallee, J.P., Schindler, T. H. (2012). Journal of Nuclear Cardiology, 19 (4), 693-703.

https://doi.org/10.1007/s12350-012-9570-5

ARFI-prepared MRgHIFU in liver: simultaneous mapping of ARFI-displacement and temperature elevation, using a fast GRE-EPI sequence

Auboiroux, V., Viallon, M., Roland, J., Hyacinthe, J.N., Petrusca, L., Morel, D. R., Goget, T., Terraz, S., Gross, P., Becker, C. D., Salomir, R. (2012). Magnetic Resonance in Medicine , 68 (3), 932-946.

http://doi.wiley.com/10.1002/mrm.23309

Assessment of left ventricular apical rotation in obese by Cardiovascular MR tagging

Vincenti, G. M., Hyacinthe, J.-N., Kuijer, J. P.A., Mach, F., Ratib, O., Schindler, T., Vallée, J.-P. (2011). Journal of Cardiovascular Magnetic Resonance, 13 (1), 1.

https://doi.org/10.1186/1532-429X-13-S1-P326

Magnetic resonance imaging of post-systolic shortening in a closed-chest rat model of coronary occlusion using myocardial tagging

Gardier, S., Hyacinthe, J.-N., Jorge-Costa, M., Morel, D. R., Vallée, J.-P. (2011). Journal of Cardiovascular Magnetic Resonance, 13 (1), 1.

https://doi.org/10.1186/1532-429X-13-S1-P113

Real time cardiac MRI: spline-based spatio-temporal reconstruction of spiral data

Delattre, B. M.A., Hyacinthe, J.-N., Krüger, G., Vallée, J.-P., Van De Ville, D. (2011). Journal of Cardiovascular Magnetic Resonance, 13 (1), 1.

https://doi.org/10.1186/1532-429X-13-S1-P141

Spiral demystified

Delattre, B. M. A., Heidemann, R. M., Crowe, L. A., Vallee, J.P., Hyacinthe, J.N. (2010). Magnetic Resonance Imaging, 28 (6), 862-881.

https://doi.org/10.1016/j.mri.2010.03.036

Hyperpolarizing gases via dynamic nuclear polarization and sublimation

Comment, A., Jannin, S., Hyacinthe, J.-N., Miéville, P., Sarkar, R., Ahuja, P., Vasos, P. R., Montet, X., Lazeyras, F., Vallée, J.-P., Hautle, P., Konter, J. A., van den Brandt, B., Ansermet, J.-Ph., Gruetter, R., Bodenhausen, G. (2010). Physical Review Letters, 105 (1), 018104.

https://doi.org/10.1103/PhysRevLett.105.018104

Myocardial infarction quantification with Manganese-Enhanced MRI (MEMRI) in mice using a 3T clinical scanner

Delattre, B. M. A., Braunersreuther, V., Hyacinthe, J.N., Crowe, L. A., Mach, F., Vallee, J.P. (2010). NMR in Biomedicine, 23 (5), 503-513.

http://doi.wiley.com/10.1002/nbm.1489

The role of imaging and molecular imaging in the early detection of metabolic and cardiovascular dysfunctions

Montet-Abou, K., Viallon, M., Hyacinthe, J.-N., Delattre, B., Vallee, J.-P., Didier, D., Croisille, P., Montet, X. (2010). International Journal of Obesity, 34 Suppl 2, S67-81.

http://www.nature.com/doifinder/10.1038/ijo.2010.242

In vivo labelling of resting monocytes in the reticuloendothelial system with fluorescent iron oxide nanoparticles prior to injury reveals that they are mobilized to infarcted myocardium

Montet-Abou, K., Daire, J.L., Hyacinthe, J.N., Jorge-Costa, M., Grosdemange, K., Mach, F., Petri-Fink, A., Hofmann, H., Morel, D. R., Vallee, J.P., Montet, X. (2010). European Heart Journal, 31 (11), 1410-1420.

https://doi.org/10.1093/eurheartj/ehp547

SNR enhancement of highly-accelerated real-time cardiac MRI acquisitions based on non-local means algorithm

Naegel, B., Cernicanu, A., Hyacinthe, J.N., Tognolini, M., Vallee, J.P. (2009). Medical Image Analysis, 13 (4), 598-608.

https://doi.org/10.1016/j.media.2009.05.006

In vivo myocardial infarct area at risk assessment in the rat using manganese enhanced magnetic resonance imaging (MEMRI) at 1.5T

Daire, J. L., Hyacinthe, J.-N., Tatar, I., Montet-Abou, K., Ivancevic, M. K., Masterson, K., Jorge-Costa, M., Morel, D. R., Vallee, J.-P. (2008). Magnetic Resonance in Medicine, 59 (6), 1422-1430.

http://doi.wiley.com/10.1002/mrm.21493

Cine and tagged cardiovascular magnetic resonance imaging in normal rat at 1.5 T: a rest and stress study

Daire, J.-L., Jacob, J.-P., Hyacinthe, J.-N., Croisille, P., Montet-Abou, K., Richter, S., Botsikas, D., Lepetit-Coiffe, M., Morel, D. R., Vallee, J.-P. (2008). Journal of Cardiovascular Magnetic Resonance, 10 (1), 48.

http://jcmr-online.biomedcentral.com/articles/10.1186/1532-429X-10-48

Feasibility of complementary spatial modulation of magnetization tagging in the rat heart after manganese injection

Hyacinthe, J.-N., Ivancevic, M. K., Daire, J. L., Vallee, J.-P. (2008). NMR in Biomedicine
, 21 (1), 15-21.

http://doi.wiley.com/10.1002/nbm.1144

High-resolution complementary spatial modulation of magnetization (CSPAMM) rat heart tagging on a 1.5 Tesla Clinical Magnetic Resonance System: a preliminary feasibility study

Ivancevic, M. K., Daire, J.-L., Hyacinthe, J.-N., Crelier, G., Kozerke, S., Montet-Abou, K., Gunes-Tatar, I., Morel, D. R., Vallee, J.-P. (2007). Investigative Radiology, 42 (3), 204-210.

https://doi.org/10.1097/01.rli.0000255646.58831.4b

Extrema temporal chaining: A new method for computing the 2D-displacement field of the heart from tagged MRI

Jacob, J.-P., Vachier, C., Morel, J.-M., Daire, J.-L., Hyacinthe, J.-N., Vallee, J.-P. (2006). Advanced Concepts for Intelligent Vision Systems, Proceedings, 4179, 897-908.

https://doi.org/10.1007/11864349_82

Optimization of cardiac cine in the rat on a clinical 1.5-T MR system

Montet-Abou, K., Daire, J. L., Ivancevic, M. K., Hyacinthe, J.-N., Nguyen, D., Jorge-Costa, M., Morel, D. R., Vallee, J.-P. (2006). Magnetic Resonance Materials in Physics, Biology and Medicine, 19 (3), 144-151.

http://link.springer.com/10.1007/s10334-006-0037-z