Anastasios Kanellakopoulos
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Des expériences avec des cultures de laboratoire enrichies avec des isotopes stables de strontium ont démontré que certains microorganismes incorporent efficacement cet élément étant ainsi capables de diminuer significativement sa concentration dans le milieu de culture. En particulier, certaines espèces de microalgues vertes de la classe des Chlorodendrophycées sont des candidates potentielles pour le développement de nouvelles techniques de bio-remédiation du strontium : celles-ci auraient lieu via la formation d’inclusions intracellulaires de carbonate de calcium amorphe enrichies en strontium. <\/p>\r\n\r\n
Ce projet cherche à vérifier si ces algues, déjà testées en laboratoire avec des isotopes stables de strontium, sont aussi capables d’accumuler le strontium 90 en présence de concentrations naturelles des isotopes stables et si cette accumulation permettrait d’envisager leur utilisation comme méthode de bioremédiation.<\/p>"}},"id":1042732,"acronym":null,"mainTitle":"Projet Microbials: Des algues unicellulaires comme agents de bio-rem\u00e9diation du strontium 90?","mainDescription":"
Le strontium 90 est un radionucléide d’origine artificielle émis lors d’accidents d’installations nucléaires (Tchernobyl, Fukushima Daiichi) et des essais nucléaires militaires (Pacifique Sud, Semipalatinsk). Il entre aussi, pour une faible part, dans les rejets d’effluents des centrales nucléaires et, en proportion plus grande, dans les effluents liquides des usines de retraitement (La Hague, Sellafield). Le strontium 90 est radiotoxique; en raison de ses similitudes chimiques et biochimiques avec le calcium, plus de 99% du strontium dans les organismes vivants existe dans les os et les dents. L'exposition interne à long terme par le strontium 90 accumulé et son radionucléide descendant, l'yttrium 90, augmente le risque de leucémie et de cancer du squelette.<\/p>\r\n\r\n
Des expériences avec des cultures de laboratoire enrichies avec des isotopes stables de strontium ont démontré que certains microorganismes incorporent efficacement cet élément étant ainsi capables de diminuer significativement sa concentration dans le milieu de culture. En particulier, certaines espèces de microalgues vertes de la classe des Chlorodendrophycées sont des candidates potentielles pour le développement de nouvelles techniques de bio-remédiation du strontium : celles-ci auraient lieu via la formation d’inclusions intracellulaires de carbonate de calcium amorphe enrichies en strontium. <\/p>\r\n\r\n
Ce projet cherche à vérifier si ces algues, déjà testées en laboratoire avec des isotopes stables de strontium, sont aussi capables d’accumuler le strontium 90 en présence de concentrations naturelles des isotopes stables et si cette accumulation permettrait d’envisager leur utilisation comme méthode de bioremédiation.<\/p>","value":null,"finished":true,"pilier":6,"url":null,"keywords":null,"disciplines":[],"axes":[],"partners":[],"collaborators":[{"id":4270629,"role":"ME","display":true,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"stavroul.pallada","project":1042732},{"id":4270630,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"anastasi.kanellak","project":1042732}],"dataHub":false,"startAt":null,"endAt":"2023-09-30T00:00:00+02:00","fundingSource":"Gebert R\u00fcf Stiftung (B\u00e2le, Suisse)","publications":[],"projectUrl":"https:\/\/pubs.rsc.org\/en\/content\/articlehtml\/2024\/em\/d3em00336a","repo_name":null}}
{"id":4270624,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"anastasi.kanellak","project":{"translations":{"fr":{"id":23451,"title":"GAMMA-MRI: the future of molecular imaging","description":"Gamma-MRI will develop a clinical molecular imaging device based on the physical principle of anisotropic gamma emission from hyperpolarised metastable xenon. In the strategic move from “one size fits all” to personalised medicine, molecular imaging plays an essential role. However, despite significant technological advances in the last decades, medical imaging (especially for the brain) relies heavily on very expensive, complex and bulky machines. Moreover, MRI suffers from low sensitivity, only partially compensated by the recent advances in hyperpolarisation. On the other hand, the very sensitive PET and SPECT imaging modalities offer limited spatial resolution. Besides those trade-offs, the limited access to suitable devices still hinders the applicability of medical imaging to address major healthcare challenges in brain-related pathologies, even in Europe. Stroke alone is the second cause of death and the third cause of disability worldwide. The evolution of ischaemic damage varies much among patients. To achieve significant improvement in the outcome of the patients, a careful selection of the treatment path guided by images of the ischaemic brain, in a narrow time window of just a few hours is crucial. Unfortunately, point-of-care molecular imaging that could speed up patient management barely exists. Gamma-MRI is a game-changer imaging technology, combining the high sensitivity of gamma ray detection and the high resolution and flexibility of MRI, bringing down by multiple fold the cost of molecular imaging. Six closely interlinked work packages will cover: production of hyperpolarised gamma-emitting xenon isomers; preserving hyperpolarisation until delivery to targeted organ; developing advanced image acquisition and reconstruction using physics- and artificial intelligence- based approaches; designing and assembling the prototype upon a low field versatile magnet; and implementing the first preclinical Gamma-MRI brain imaging experiment.<\/p>"}},"id":1004334,"acronym":null,"mainTitle":"GAMMA-MRI: the future of molecular imaging","mainDescription":"
Gamma-MRI will develop a clinical molecular imaging device based on the physical principle of anisotropic gamma emission from hyperpolarised metastable xenon. In the strategic move from “one size fits all” to personalised medicine, molecular imaging plays an essential role. However, despite significant technological advances in the last decades, medical imaging (especially for the brain) relies heavily on very expensive, complex and bulky machines. Moreover, MRI suffers from low sensitivity, only partially compensated by the recent advances in hyperpolarisation. On the other hand, the very sensitive PET and SPECT imaging modalities offer limited spatial resolution. Besides those trade-offs, the limited access to suitable devices still hinders the applicability of medical imaging to address major healthcare challenges in brain-related pathologies, even in Europe. Stroke alone is the second cause of death and the third cause of disability worldwide. The evolution of ischaemic damage varies much among patients. To achieve significant improvement in the outcome of the patients, a careful selection of the treatment path guided by images of the ischaemic brain, in a narrow time window of just a few hours is crucial. Unfortunately, point-of-care molecular imaging that could speed up patient management barely exists. Gamma-MRI is a game-changer imaging technology, combining the high sensitivity of gamma ray detection and the high resolution and flexibility of MRI, bringing down by multiple fold the cost of molecular imaging. Six closely interlinked work packages will cover: production of hyperpolarised gamma-emitting xenon isomers; preserving hyperpolarisation until delivery to targeted organ; developing advanced image acquisition and reconstruction using physics- and artificial intelligence- based approaches; designing and assembling the prototype upon a low field versatile magnet; and implementing the first preclinical Gamma-MRI brain imaging experiment.<\/p>","value":"3372392.5","finished":false,"pilier":6,"url":null,"keywords":null,"disciplines":[],"axes":[],"partners":[],"collaborators":[{"id":4270622,"role":"RP","display":true,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"stavroul.pallada","project":1004334},{"id":4270623,"role":"ME","display":true,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"nicola.giandome","project":1004334},{"id":4270624,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"anastasi.kanellak","project":1004334},{"id":4270625,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"quentin.rogliard","project":1004334},{"id":4270626,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"ashley.cooper","project":1004334}],"dataHub":false,"startAt":"2021-05-01T00:00:00+02:00","endAt":"2024-09-30T00:00:00+02:00","fundingSource":"EUROPEAN INNOVATION COUNCIL AND SMES EXECUTIVE AGENCY (EISMEA)","publications":[],"projectUrl":"https:\/\/gamma-mri.eu","repo_name":null}}
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