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Joao Pinheiro Marques
joao.marques
9569292057
Pinheiro Marques
Joao
joao.marques@hesge.ch
fr
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After having validated this initial healthy endometrium model, we have interconnected to another compartment for the invaded organ.\r\nWe have characterized human epithelial (Ishikawa cells) and stromal cells (ESS-1 cells) and built a human physiological model of the endometrium. We have simulated different aspects of the female reproductive system such as survival and multiplication rate depending on various concentrations of two key hormones (Progesterone and Oestrogen). For the pathological endometriosis in vitro model, we confirmed the integration capacity of endometrial cells on a potentially invaded organ such as intestinal construct (Caco-2) or fibroblast cells. Altogether, we have generated proof of concept data, and we are currently presenting the work in several conferences (MPS, WC13, BMT) and a scientific conference paper (submitted BMT). 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