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Hepia et Unige entendent :\r\na) proposer des mandats de prestations et mettre \u00e0 disposition des initiatives individuelles (acad\u00e9miques ou industrielles) des comp\u00e9tences et des technologies de haut niveau pr\u00e9sentes aupr\u00e8s des hautes \u00e9coles susmentionn\u00e9es ;\r\nb) valoriser les laboratoires existants et rendre tout nouvel investissement efficient ;\r\nc) offrir un guichet unique aux entreprises et leur facilit\u00e9 l'acc\u00e8s aux \u00e9quipements et aux  groupes de recherche.\r\n"}},"id":106607,"acronym":"LTA_2021","mainTitle":"LTA 2021.","mainDescription":"Hepia et Unige unissent leurs efforts afin de cr\u00e9er le Laboratoire de Technologie Avanc\u00e9e, ci-apr\u00e8s LTA, une infrastructure con\u00e7ue pour valoriser le savoir-faire et les \u00e9quipements de pointe de l'Universit\u00e9 de Gen\u00e8ve et de la HES-SO Gen\u00e8ve aupr\u00e8s des industries. Porte d'entr\u00e9e vers pr\u00e8s de 20 groupes de recherche et plus de 100 \u00e9quipements et savoir-faire, le LTA apporte des solutions techniques originales aux petites, moyennes et grandes entreprises.\r\n\r\nObjectifs :\r\n\r\nPar la cr\u00e9ation du LTA, . Hepia et Unige entendent :\r\na) proposer des mandats de prestations et mettre \u00e0 disposition des initiatives individuelles (acad\u00e9miques ou industrielles) des comp\u00e9tences et des technologies de haut niveau pr\u00e9sentes aupr\u00e8s des hautes \u00e9coles susmentionn\u00e9es ;\r\nb) valoriser les laboratoires existants et rendre tout nouvel investissement efficient ;\r\nc) offrir un guichet unique aux entreprises et leur facilit\u00e9 l'acc\u00e8s aux \u00e9quipements et aux  groupes de recherche.\r\n","value":null,"finished":true,"pilier":5,"url":null,"keywords":null,"disciplines":[],"axes":[],"partners":[{"id":1861553,"name":"","confidential":false,"types":[{"id":3,"code":"RP"},{"id":4,"code":"CO"}],"institution":"hepia inSTI","class":"academique"},{"id":1861554,"name":"Stucki Nicolas","confidential":false,"types":[{"id":3,"code":"RP"},{"id":4,"code":"CO"}],"institution":"hepia inSTI","class":"academique"}],"collaborators":[{"id":7861070,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"dominiqu.trinchan","project":106607},{"id":7861071,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"axel.baxarias","project":106607},{"id":7861072,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"sebastie.carlesso","project":106607},{"id":7861073,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"malek.fedel","project":106607},{"id":7861074,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"herve.sthioul","project":106607},{"id":7861075,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"martina.zselysch","project":106607},{"id":7861076,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"gilles.triscone","project":106607},{"id":7861077,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":false,"displayAcademicPartner":false,"displayProfessionalPartner":false,"collaborator":"flavio.noca","project":106607},{"id":7861078,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"roland.rozsnyo","project":106607},{"id":7861079,"role":"RP","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"nicolas.stucki","project":106607}],"dataHub":true,"startAt":"2021-01-01T00:00:00+01:00","endAt":"2022-06-30T00:00:00+02:00","fundingSource":"Universit\u00e9 de Gen\u00e8ve","publications":[],"projectUrl":null,"repo_name":null}}

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Hepia et Unige entendent :\r\na) proposer des mandats de prestations et mettre \u00e0 disposition des initiatives individuelles (acad\u00e9miques ou industrielles) des comp\u00e9tences et des technologies de haut niveau pr\u00e9sentes aupr\u00e8s des hautes \u00e9coles susmentionn\u00e9es ;\r\nb) valoriser les laboratoires existants et rendre tout nouvel investissement efficient ;\r\nc) offrir un guichet unique aux entreprises et leur facilit\u00e9 l'acc\u00e8s aux \u00e9quipements et aux  groupes de recherche.\r\n"},"en":{"id":14302,"title":"LTA 2020.","description":"Hepia et Unige unissent leurs efforts afin de cr\u00e9er le Laboratoire de Technologie Avanc\u00e9e, ci-apr\u00e8s LTA, une infrastructure con\u00e7ue pour valoriser le savoir-faire et les \u00e9quipements de pointe de l'Universit\u00e9 de Gen\u00e8ve et de la HES-SO Gen\u00e8ve aupr\u00e8s des industries. Porte d'entr\u00e9e vers pr\u00e8s de 20 groupes de recherche et plus de 100 \u00e9quipements et savoir-faire, le LTA apporte des solutions techniques originales aux petites, moyennes et grandes entreprises.\r\n\r\nObjectifs :\r\n\r\nPar la cr\u00e9ation du LTA, . Hepia et Unige entendent :\r\na) proposer des mandats de prestations et mettre \u00e0 disposition des initiatives individuelles (acad\u00e9miques ou industrielles) des comp\u00e9tences et des technologies de haut niveau pr\u00e9sentes aupr\u00e8s des hautes \u00e9coles susmentionn\u00e9es ;\r\nb) valoriser les laboratoires existants et rendre tout nouvel investissement efficient ;\r\nc) offrir un guichet unique aux entreprises et leur facilit\u00e9 l'acc\u00e8s aux \u00e9quipements et aux  groupes de recherche.\r\n"},"de":{"id":14303,"title":"LTA 2020.","description":"Hepia et Unige unissent leurs efforts afin de cr\u00e9er le Laboratoire de Technologie Avanc\u00e9e, ci-apr\u00e8s LTA, une infrastructure con\u00e7ue pour valoriser le savoir-faire et les \u00e9quipements de pointe de l'Universit\u00e9 de Gen\u00e8ve et de la HES-SO Gen\u00e8ve aupr\u00e8s des industries. Porte d'entr\u00e9e vers pr\u00e8s de 20 groupes de recherche et plus de 100 \u00e9quipements et savoir-faire, le LTA apporte des solutions techniques originales aux petites, moyennes et grandes entreprises.\r\n\r\nObjectifs :\r\n\r\nPar la cr\u00e9ation du LTA, . Hepia et Unige entendent :\r\na) proposer des mandats de prestations et mettre \u00e0 disposition des initiatives individuelles (acad\u00e9miques ou industrielles) des comp\u00e9tences et des technologies de haut niveau pr\u00e9sentes aupr\u00e8s des hautes \u00e9coles susmentionn\u00e9es ;\r\nb) valoriser les laboratoires existants et rendre tout nouvel investissement efficient ;\r\nc) offrir un guichet unique aux entreprises et leur facilit\u00e9 l'acc\u00e8s aux \u00e9quipements et aux  groupes de recherche.\r\n"}},"id":98772,"acronym":"LTA_2020","mainTitle":"LTA 2020.","mainDescription":"Hepia et Unige unissent leurs efforts afin de cr\u00e9er le Laboratoire de Technologie Avanc\u00e9e, ci-apr\u00e8s LTA, une infrastructure con\u00e7ue pour valoriser le savoir-faire et les \u00e9quipements de pointe de l'Universit\u00e9 de Gen\u00e8ve et de la HES-SO Gen\u00e8ve aupr\u00e8s des industries. Porte d'entr\u00e9e vers pr\u00e8s de 20 groupes de recherche et plus de 100 \u00e9quipements et savoir-faire, le LTA apporte des solutions techniques originales aux petites, moyennes et grandes entreprises.\r\n\r\nObjectifs :\r\n\r\nPar la cr\u00e9ation du LTA, . 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{"id":7786837,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"dominiqu.trinchan","project":{"translations":{"fr":{"id":7597,"title":"In vitro models for toxicity assessment\r\n","description":"\"3 Neurotoxicology in vitro\r\n3.2 Human in vitro 2D and 3D models of mature neural networks for Neurotoxicity assessment\r\nProject Leader: Luc Stoppini\r\n Partners: F. Tschudi-Monnet; C. Degeyter; Alex Scherl\r\nFinal histological characterization of 2D and 3 D human neural networks: \r\nWe have generated human neural cells and tissue derived from hESCs. We will perform the final characterization of the different 2D and 3 D neural cultures.\r\nImmunostainings of the different neural makers to assess the presence and the organization of the different cells types (GFAP: for astrocytes; CNPase and MBP for oligodendrocytes; MAP2, NF,NeuN for neurones). 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Spontaneous as well as evoked field potentials will be recorded in control nervous tissues and after exposure of the neuro-glial networks to reference pharmacological molecules to verify that the nervous tissues are responding similarly to primary neural tissues.\r\nDeliverable: Report on the 3D neural tissue electrophysiological characterization. 01.01.2013\r\n31.06.2013\r\nAcute neurotoxicity studies: \r\nAcute dose-responses of neurotoxicants will be performed in 3D human neural networks to assess their effects on the neuronal activity in vitro by means of electrophysiological M.E.A. recordings. \r\nDeliverable: Report on the 3D neural tissue electrophysiological characterization for reference neurotoxic compounds. 01.07.2013\r\n31.12.2013\r\nGene expression profile in 3D neural tissues: \r\nGene expression profile: We will verify gene expression toxicity signatures using different types of xenobiotics (control and known to induce adverse effects on neural tissues). Human neuro-glial networks will be treated acutely or repeatedly with different concentrations of a series of different types of neurotoxicants. mRNA will be isolated at different culture time points and measured by RT-qPCR. \r\nDeliverable: Report on the 3D neural tissue gene profile of specific markers in control and using reference neurotoxic molecules. 01.04.2013\r\n31.12.2013\r\nProteomic analyses of 3D human neural tissues: \r\nThe proteomic analysis profile will be performed in control conditions and after treatment of 3 D human neural tissues with reference neurotoxic molecules.\r\nDeliverable: Report on proteomic neurotoxic profile of 3D human neural tissues. 01.03.2013\r\n31.12.2013\r\nFunctional activities of 2D neural networks using calcium mobilization assay: \r\nMeasurement of calcium mobilization: Variations in the concentration of intracellular calcium, which is known to trigger a number of events including the release of synaptic transmitter, will be measured using Fluo-4 Flexstation Calcium assay kit. Human neuronal cells will be grown in 96 well plates to fit to the workflow system. Reference toxic molecules will be tested to validate the approach.\r\nDeliverable: Report on the validation of the Calcium mobilization as a functional assay to assess neurotoxicity. 01.03.2013\r\n31.12.2013\r\nFunctional activities of 2D neural networks using Neurotransmitter Transporter Uptake Assay: \r\nHomogeneous Neurotransmitter Transporter Uptake Assay: The assay includes a fluorescent indicator dye that mimics the neurotransmitters serotonin, norepinephrine, and dopamine which are actively transported into the cells via the specific neurotransmitter transporters. The fluorescent substrate that mimics the biogenic amine neurotransmitters is then taken up into the cell through those specific transporters, resulting in increased intracellular fluorescence intensity. This homogeneous, fluorescent assay is robust, sensitive, and specific, and"},"en":{"id":7598,"title":"In vitro models for toxicity assessment\r\n","description":"\"3 Neurotoxicology in vitro\r\n3.2 Human in vitro 2D and 3D models of mature neural networks for Neurotoxicity assessment\r\nProject Leader: Luc Stoppini\r\n Partners: F. Tschudi-Monnet; C. Degeyter; Alex Scherl\r\nFinal histological characterization of 2D and 3 D human neural networks: \r\nWe have generated human neural cells and tissue derived from hESCs. We will perform the final characterization of the different 2D and 3 D neural cultures.\r\nImmunostainings of the different neural makers to assess the presence and the organization of the different cells types (GFAP: for astrocytes; CNPase and MBP for oligodendrocytes; MAP2, NF,NeuN for neurones). We will also perform some electron microscopy studies to assess the precise morphology of the differentiated nervous tissues.\r\nDeliverable: Report on the histological characterization 01.01.2013\r\n31.05.2013\r\nFunctional Characterization of the neural networks generated from hESCs by electrophysiological studies: \r\nElectrophysiological recordings will be performed using neural tissues generated from hESCs and laid down onto MEAs. Spontaneous as well as evoked field potentials will be recorded in control nervous tissues and after exposure of the neuro-glial networks to reference pharmacological molecules to verify that the nervous tissues are responding similarly to primary neural tissues.\r\nDeliverable: Report on the 3D neural tissue electrophysiological characterization. 01.01.2013\r\n31.06.2013\r\nAcute neurotoxicity studies: \r\nAcute dose-responses of neurotoxicants will be performed in 3D human neural networks to assess their effects on the neuronal activity in vitro by means of electrophysiological M.E.A. recordings. \r\nDeliverable: Report on the 3D neural tissue electrophysiological characterization for reference neurotoxic compounds. 01.07.2013\r\n31.12.2013\r\nGene expression profile in 3D neural tissues: \r\nGene expression profile: We will verify gene expression toxicity signatures using different types of xenobiotics (control and known to induce adverse effects on neural tissues). Human neuro-glial networks will be treated acutely or repeatedly with different concentrations of a series of different types of neurotoxicants. mRNA will be isolated at different culture time points and measured by RT-qPCR. \r\nDeliverable: Report on the 3D neural tissue gene profile of specific markers in control and using reference neurotoxic molecules. 01.04.2013\r\n31.12.2013\r\nProteomic analyses of 3D human neural tissues: \r\nThe proteomic analysis profile will be performed in control conditions and after treatment of 3 D human neural tissues with reference neurotoxic molecules.\r\nDeliverable: Report on proteomic neurotoxic profile of 3D human neural tissues. 01.03.2013\r\n31.12.2013\r\nFunctional activities of 2D neural networks using calcium mobilization assay: \r\nMeasurement of calcium mobilization: Variations in the concentration of intracellular calcium, which is known to trigger a number of events including the release of synaptic transmitter, will be measured using Fluo-4 Flexstation Calcium assay kit. Human neuronal cells will be grown in 96 well plates to fit to the workflow system. Reference toxic molecules will be tested to validate the approach.\r\nDeliverable: Report on the validation of the Calcium mobilization as a functional assay to assess neurotoxicity. 01.03.2013\r\n31.12.2013\r\nFunctional activities of 2D neural networks using Neurotransmitter Transporter Uptake Assay: \r\nHomogeneous Neurotransmitter Transporter Uptake Assay: The assay includes a fluorescent indicator dye that mimics the neurotransmitters serotonin, norepinephrine, and dopamine which are actively transported into the cells via the specific neurotransmitter transporters. The fluorescent substrate that mimics the biogenic amine neurotransmitters is then taken up into the cell through those specific transporters, resulting in increased intracellular fluorescence intensity. This homogeneous, fluorescent assay is robust, sensitive, and specific, and"},"de":{"id":7599,"title":"In vitro models for toxicity assessment\r\n","description":"\"3 Neurotoxicology in vitro\r\n3.2 Human in vitro 2D and 3D models of mature neural networks for Neurotoxicity assessment\r\nProject Leader: Luc Stoppini\r\n Partners: F. Tschudi-Monnet; C. Degeyter; Alex Scherl\r\nFinal histological characterization of 2D and 3 D human neural networks: \r\nWe have generated human neural cells and tissue derived from hESCs. We will perform the final characterization of the different 2D and 3 D neural cultures.\r\nImmunostainings of the different neural makers to assess the presence and the organization of the different cells types (GFAP: for astrocytes; CNPase and MBP for oligodendrocytes; MAP2, NF,NeuN for neurones). We will also perform some electron microscopy studies to assess the precise morphology of the differentiated nervous tissues.\r\nDeliverable: Report on the histological characterization 01.01.2013\r\n31.05.2013\r\nFunctional Characterization of the neural networks generated from hESCs by electrophysiological studies: \r\nElectrophysiological recordings will be performed using neural tissues generated from hESCs and laid down onto MEAs. Spontaneous as well as evoked field potentials will be recorded in control nervous tissues and after exposure of the neuro-glial networks to reference pharmacological molecules to verify that the nervous tissues are responding similarly to primary neural tissues.\r\nDeliverable: Report on the 3D neural tissue electrophysiological characterization. 01.01.2013\r\n31.06.2013\r\nAcute neurotoxicity studies: \r\nAcute dose-responses of neurotoxicants will be performed in 3D human neural networks to assess their effects on the neuronal activity in vitro by means of electrophysiological M.E.A. recordings. \r\nDeliverable: Report on the 3D neural tissue electrophysiological characterization for reference neurotoxic compounds. 01.07.2013\r\n31.12.2013\r\nGene expression profile in 3D neural tissues: \r\nGene expression profile: We will verify gene expression toxicity signatures using different types of xenobiotics (control and known to induce adverse effects on neural tissues). Human neuro-glial networks will be treated acutely or repeatedly with different concentrations of a series of different types of neurotoxicants. mRNA will be isolated at different culture time points and measured by RT-qPCR. \r\nDeliverable: Report on the 3D neural tissue gene profile of specific markers in control and using reference neurotoxic molecules. 01.04.2013\r\n31.12.2013\r\nProteomic analyses of 3D human neural tissues: \r\nThe proteomic analysis profile will be performed in control conditions and after treatment of 3 D human neural tissues with reference neurotoxic molecules.\r\nDeliverable: Report on proteomic neurotoxic profile of 3D human neural tissues. 01.03.2013\r\n31.12.2013\r\nFunctional activities of 2D neural networks using calcium mobilization assay: \r\nMeasurement of calcium mobilization: Variations in the concentration of intracellular calcium, which is known to trigger a number of events including the release of synaptic transmitter, will be measured using Fluo-4 Flexstation Calcium assay kit. Human neuronal cells will be grown in 96 well plates to fit to the workflow system. Reference toxic molecules will be tested to validate the approach.\r\nDeliverable: Report on the validation of the Calcium mobilization as a functional assay to assess neurotoxicity. 01.03.2013\r\n31.12.2013\r\nFunctional activities of 2D neural networks using Neurotransmitter Transporter Uptake Assay: \r\nHomogeneous Neurotransmitter Transporter Uptake Assay: The assay includes a fluorescent indicator dye that mimics the neurotransmitters serotonin, norepinephrine, and dopamine which are actively transported into the cells via the specific neurotransmitter transporters. The fluorescent substrate that mimics the biogenic amine neurotransmitters is then taken up into the cell through those specific transporters, resulting in increased intracellular fluorescence intensity. This homogeneous, fluorescent assay is robust, sensitive, and specific, and"}},"id":38824,"acronym":"SCAHT4_2014","mainTitle":"In vitro models for toxicity assessment\r\n","mainDescription":"\"3 Neurotoxicology in vitro\r\n3.2 Human in vitro 2D and 3D models of mature neural networks for Neurotoxicity assessment\r\nProject Leader: Luc Stoppini\r\n Partners: F. Tschudi-Monnet; C. Degeyter; Alex Scherl\r\nFinal histological characterization of 2D and 3 D human neural networks: \r\nWe have generated human neural cells and tissue derived from hESCs. We will perform the final characterization of the different 2D and 3 D neural cultures.\r\nImmunostainings of the different neural makers to assess the presence and the organization of the different cells types (GFAP: for astrocytes; CNPase and MBP for oligodendrocytes; MAP2, NF,NeuN for neurones). We will also perform some electron microscopy studies to assess the precise morphology of the differentiated nervous tissues.\r\nDeliverable: Report on the histological characterization 01.01.2013\r\n31.05.2013\r\nFunctional Characterization of the neural networks generated from hESCs by electrophysiological studies: \r\nElectrophysiological recordings will be performed using neural tissues generated from hESCs and laid down onto MEAs. Spontaneous as well as evoked field potentials will be recorded in control nervous tissues and after exposure of the neuro-glial networks to reference pharmacological molecules to verify that the nervous tissues are responding similarly to primary neural tissues.\r\nDeliverable: Report on the 3D neural tissue electrophysiological characterization. 01.01.2013\r\n31.06.2013\r\nAcute neurotoxicity studies: \r\nAcute dose-responses of neurotoxicants will be performed in 3D human neural networks to assess their effects on the neuronal activity in vitro by means of electrophysiological M.E.A. recordings. \r\nDeliverable: Report on the 3D neural tissue electrophysiological characterization for reference neurotoxic compounds. 01.07.2013\r\n31.12.2013\r\nGene expression profile in 3D neural tissues: \r\nGene expression profile: We will verify gene expression toxicity signatures using different types of xenobiotics (control and known to induce adverse effects on neural tissues). Human neuro-glial networks will be treated acutely or repeatedly with different concentrations of a series of different types of neurotoxicants. mRNA will be isolated at different culture time points and measured by RT-qPCR. \r\nDeliverable: Report on the 3D neural tissue gene profile of specific markers in control and using reference neurotoxic molecules. 01.04.2013\r\n31.12.2013\r\nProteomic analyses of 3D human neural tissues: \r\nThe proteomic analysis profile will be performed in control conditions and after treatment of 3 D human neural tissues with reference neurotoxic molecules.\r\nDeliverable: Report on proteomic neurotoxic profile of 3D human neural tissues. 01.03.2013\r\n31.12.2013\r\nFunctional activities of 2D neural networks using calcium mobilization assay: \r\nMeasurement of calcium mobilization: Variations in the concentration of intracellular calcium, which is known to trigger a number of events including the release of synaptic transmitter, will be measured using Fluo-4 Flexstation Calcium assay kit. Human neuronal cells will be grown in 96 well plates to fit to the workflow system. Reference toxic molecules will be tested to validate the approach.\r\nDeliverable: Report on the validation of the Calcium mobilization as a functional assay to assess neurotoxicity. 01.03.2013\r\n31.12.2013\r\nFunctional activities of 2D neural networks using Neurotransmitter Transporter Uptake Assay: \r\nHomogeneous Neurotransmitter Transporter Uptake Assay: The assay includes a fluorescent indicator dye that mimics the neurotransmitters serotonin, norepinephrine, and dopamine which are actively transported into the cells via the specific neurotransmitter transporters. The fluorescent substrate that mimics the biogenic amine neurotransmitters is then taken up into the cell through those specific transporters, resulting in increased intracellular fluorescence intensity. This homogeneous, fluorescent assay is robust, sensitive, and specific, and","value":"340000.00","finished":true,"pilier":6,"url":null,"keywords":null,"disciplines":[],"axes":[],"partners":[],"collaborators":[{"id":7786837,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"dominiqu.trinchan","project":38824},{"id":7786838,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"laetitia.nikles","project":38824},{"id":7786839,"role":"ME","display":true,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"adrien.roux","project":38824},{"id":7786840,"role":"RP","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"luc.stoppini","project":38824}],"dataHub":true,"startAt":"2014-04-01T00:00:00+02:00","endAt":"2014-12-31T00:00:00+01:00","fundingSource":"UNIGE; hepia inSTI; hepia inSTI","publications":[],"projectUrl":null,"repo_name":null}}

{"id":7786581,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"dominiqu.trinchan","project":{"translations":{"fr":{"id":7042,"title":"In vitro models for toxicity assessement.","description":"\"3 Neurotoxicology in vitro\r\n3.2 Human in vitro 2D and 3D models of mature neural networks for Neurotoxicity assessment\r\n\r\nProject Leader: Luc Stoppini\r\n Partners: F. Tschudi-Monnet; C. Degeyter; Alex Scherl\r\nFinal histological characterization of 2D and 3 D human neural networks: \r\nWe have generated human neural cells and tissue derived from hESCs. We will perform the final characterization of the different 2D and 3 D neural cultures.\r\nImmunostainings of the different neural makers to assess the presence and the organization of the different cells types (GFAP: for astrocytes; CNPase and MBP for oligodendrocytes; MAP2, NF,NeuN for neurones). We will also perform some electron microscopy studies to assess the precise morphology of the differentiated nervous tissues.\r\nDeliverable: Report on the histological characterization 01.01.2013\r\n31.05.2013\r\nFunctional Characterization of the neural networks generated from hESCs by electrophysiological studies: \r\nElectrophysiological recordings will be performed using neural tissues generated from hESCs and laid down onto MEAs. Spontaneous as well as evoked field potentials will be recorded in control nervous tissues and after exposure of the neuro-glial networks to reference pharmacological molecules to verify that the nervous tissues are responding similarly to primary neural tissues.\r\nDeliverable: Report on the 3D neural tissue electrophysiological characterization. 01.01.2013\r\n31.06.2013\r\nAcute neurotoxicity studies: \r\nAcute dose-responses of neurotoxicants will be performed in 3D human neural networks to assess their effects on the neuronal activity in vitro by means of electrophysiological M.E.A. recordings. \r\nDeliverable: Report on the 3D neural tissue electrophysiological characterization for reference neurotoxic compounds. 01.07.2013\r\n31.12.2013\r\nGene expression profile in 3D neural tissues: \rGene expression profile: We will verify gene expression toxicity signatures using different types of xenobiotics (control and known to induce adverse effects on neural tissues). Human neuro-glial networks will be treated acutely or repeatedly with different concentrations of a series of different types of neurotoxicants. mRNA will be isolated at different culture time points and measured by RT-qPCR. \r\nDeliverable: Report on the 3D neural tissue gene profile of specific markers in control and using reference neurotoxic molecules. 01.04.2013\r\n31.12.2013\r\nProteomic analyses of 3D human neural tissues: \r\nThe proteomic analysis profile will be performed in control conditions and after treatment of 3 D human neural tissues with reference neurotoxic molecules.\r\nDeliverable: Report on proteomic neurotoxic profile of 3D human neural tissues. 01.03.2013\r\n31.12.2013\r\nFunctional activities of 2D neural networks using calcium mobilization assay: \r\nMeasurement of calcium mobilization: Variations in the concentration of intracellular calcium, which is known to trigger a number of events including the release of synaptic transmitter, will be measured using Fluo-4 Flexstation Calcium assay kit. Human neuronal cells will be grown in 96 well plates to fit to the workflow system. Reference toxic molecules will be tested to validate the approach.\r\nDeliverable: Report on the validation of the Calcium mobilization as a functional assay to assess neurotoxicity. 01.03.2013\r\n31.12.2013\r\nFunctional activities of 2D neural networks using Neurotransmitter Transporter Uptake Assay: \r\nHomogeneous Neurotransmitter Transporter Uptake Assay: The assay includes a fluorescent indicator dye that mimics the neurotransmitters serotonin, norepinephrine, and dopamine which are actively transported into the cells via the specific neurotransmitter transporters. The fluorescent substrate that mimics the biogenic amine neurotransmitters is then taken up into the cell through those specific transporters, resulting in increased intracellular fluorescence intensity. This homogeneous, fluorescent assay is robust, sensitive, and specific, an"},"en":{"id":7043,"title":"In vitro models for toxicity assessement.","description":"\"3 Neurotoxicology in vitro\r\n3.2 Human in vitro 2D and 3D models of mature neural networks for Neurotoxicity assessment\r\n\r\nProject Leader: Luc Stoppini\r\n Partners: F. Tschudi-Monnet; C. Degeyter; Alex Scherl\r\nFinal histological characterization of 2D and 3 D human neural networks: \r\nWe have generated human neural cells and tissue derived from hESCs. We will perform the final characterization of the different 2D and 3 D neural cultures.\r\nImmunostainings of the different neural makers to assess the presence and the organization of the different cells types (GFAP: for astrocytes; CNPase and MBP for oligodendrocytes; MAP2, NF,NeuN for neurones). We will also perform some electron microscopy studies to assess the precise morphology of the differentiated nervous tissues.\r\nDeliverable: Report on the histological characterization 01.01.2013\r\n31.05.2013\r\nFunctional Characterization of the neural networks generated from hESCs by electrophysiological studies: \r\nElectrophysiological recordings will be performed using neural tissues generated from hESCs and laid down onto MEAs. Spontaneous as well as evoked field potentials will be recorded in control nervous tissues and after exposure of the neuro-glial networks to reference pharmacological molecules to verify that the nervous tissues are responding similarly to primary neural tissues.\r\nDeliverable: Report on the 3D neural tissue electrophysiological characterization. 01.01.2013\r\n31.06.2013\r\nAcute neurotoxicity studies: \r\nAcute dose-responses of neurotoxicants will be performed in 3D human neural networks to assess their effects on the neuronal activity in vitro by means of electrophysiological M.E.A. recordings. \r\nDeliverable: Report on the 3D neural tissue electrophysiological characterization for reference neurotoxic compounds. 01.07.2013\r\n31.12.2013\r\nGene expression profile in 3D neural tissues: \rGene expression profile: We will verify gene expression toxicity signatures using different types of xenobiotics (control and known to induce adverse effects on neural tissues). Human neuro-glial networks will be treated acutely or repeatedly with different concentrations of a series of different types of neurotoxicants. mRNA will be isolated at different culture time points and measured by RT-qPCR. \r\nDeliverable: Report on the 3D neural tissue gene profile of specific markers in control and using reference neurotoxic molecules. 01.04.2013\r\n31.12.2013\r\nProteomic analyses of 3D human neural tissues: \r\nThe proteomic analysis profile will be performed in control conditions and after treatment of 3 D human neural tissues with reference neurotoxic molecules.\r\nDeliverable: Report on proteomic neurotoxic profile of 3D human neural tissues. 01.03.2013\r\n31.12.2013\r\nFunctional activities of 2D neural networks using calcium mobilization assay: \r\nMeasurement of calcium mobilization: Variations in the concentration of intracellular calcium, which is known to trigger a number of events including the release of synaptic transmitter, will be measured using Fluo-4 Flexstation Calcium assay kit. Human neuronal cells will be grown in 96 well plates to fit to the workflow system. Reference toxic molecules will be tested to validate the approach.\r\nDeliverable: Report on the validation of the Calcium mobilization as a functional assay to assess neurotoxicity. 01.03.2013\r\n31.12.2013\r\nFunctional activities of 2D neural networks using Neurotransmitter Transporter Uptake Assay: \r\nHomogeneous Neurotransmitter Transporter Uptake Assay: The assay includes a fluorescent indicator dye that mimics the neurotransmitters serotonin, norepinephrine, and dopamine which are actively transported into the cells via the specific neurotransmitter transporters. The fluorescent substrate that mimics the biogenic amine neurotransmitters is then taken up into the cell through those specific transporters, resulting in increased intracellular fluorescence intensity. This homogeneous, fluorescent assay is robust, sensitive, and specific, an"},"de":{"id":7044,"title":"In vitro models for toxicity assessement.","description":"\"3 Neurotoxicology in vitro\r\n3.2 Human in vitro 2D and 3D models of mature neural networks for Neurotoxicity assessment\r\n\r\nProject Leader: Luc Stoppini\r\n Partners: F. Tschudi-Monnet; C. Degeyter; Alex Scherl\r\nFinal histological characterization of 2D and 3 D human neural networks: \r\nWe have generated human neural cells and tissue derived from hESCs. We will perform the final characterization of the different 2D and 3 D neural cultures.\r\nImmunostainings of the different neural makers to assess the presence and the organization of the different cells types (GFAP: for astrocytes; CNPase and MBP for oligodendrocytes; MAP2, NF,NeuN for neurones). We will also perform some electron microscopy studies to assess the precise morphology of the differentiated nervous tissues.\r\nDeliverable: Report on the histological characterization 01.01.2013\r\n31.05.2013\r\nFunctional Characterization of the neural networks generated from hESCs by electrophysiological studies: \r\nElectrophysiological recordings will be performed using neural tissues generated from hESCs and laid down onto MEAs. Spontaneous as well as evoked field potentials will be recorded in control nervous tissues and after exposure of the neuro-glial networks to reference pharmacological molecules to verify that the nervous tissues are responding similarly to primary neural tissues.\r\nDeliverable: Report on the 3D neural tissue electrophysiological characterization. 01.01.2013\r\n31.06.2013\r\nAcute neurotoxicity studies: \r\nAcute dose-responses of neurotoxicants will be performed in 3D human neural networks to assess their effects on the neuronal activity in vitro by means of electrophysiological M.E.A. recordings. \r\nDeliverable: Report on the 3D neural tissue electrophysiological characterization for reference neurotoxic compounds. 01.07.2013\r\n31.12.2013\r\nGene expression profile in 3D neural tissues: \rGene expression profile: We will verify gene expression toxicity signatures using different types of xenobiotics (control and known to induce adverse effects on neural tissues). Human neuro-glial networks will be treated acutely or repeatedly with different concentrations of a series of different types of neurotoxicants. mRNA will be isolated at different culture time points and measured by RT-qPCR. \r\nDeliverable: Report on the 3D neural tissue gene profile of specific markers in control and using reference neurotoxic molecules. 01.04.2013\r\n31.12.2013\r\nProteomic analyses of 3D human neural tissues: \r\nThe proteomic analysis profile will be performed in control conditions and after treatment of 3 D human neural tissues with reference neurotoxic molecules.\r\nDeliverable: Report on proteomic neurotoxic profile of 3D human neural tissues. 01.03.2013\r\n31.12.2013\r\nFunctional activities of 2D neural networks using calcium mobilization assay: \r\nMeasurement of calcium mobilization: Variations in the concentration of intracellular calcium, which is known to trigger a number of events including the release of synaptic transmitter, will be measured using Fluo-4 Flexstation Calcium assay kit. Human neuronal cells will be grown in 96 well plates to fit to the workflow system. Reference toxic molecules will be tested to validate the approach.\r\nDeliverable: Report on the validation of the Calcium mobilization as a functional assay to assess neurotoxicity. 01.03.2013\r\n31.12.2013\r\nFunctional activities of 2D neural networks using Neurotransmitter Transporter Uptake Assay: \r\nHomogeneous Neurotransmitter Transporter Uptake Assay: The assay includes a fluorescent indicator dye that mimics the neurotransmitters serotonin, norepinephrine, and dopamine which are actively transported into the cells via the specific neurotransmitter transporters. The fluorescent substrate that mimics the biogenic amine neurotransmitters is then taken up into the cell through those specific transporters, resulting in increased intracellular fluorescence intensity. This homogeneous, fluorescent assay is robust, sensitive, and specific, an"}},"id":36062,"acronym":"SCAHT 3","mainTitle":"In vitro models for toxicity assessement.","mainDescription":"\"3 Neurotoxicology in vitro\r\n3.2 Human in vitro 2D and 3D models of mature neural networks for Neurotoxicity assessment\r\n\r\nProject Leader: Luc Stoppini\r\n Partners: F. Tschudi-Monnet; C. Degeyter; Alex Scherl\r\nFinal histological characterization of 2D and 3 D human neural networks: \r\nWe have generated human neural cells and tissue derived from hESCs. We will perform the final characterization of the different 2D and 3 D neural cultures.\r\nImmunostainings of the different neural makers to assess the presence and the organization of the different cells types (GFAP: for astrocytes; CNPase and MBP for oligodendrocytes; MAP2, NF,NeuN for neurones). We will also perform some electron microscopy studies to assess the precise morphology of the differentiated nervous tissues.\r\nDeliverable: Report on the histological characterization 01.01.2013\r\n31.05.2013\r\nFunctional Characterization of the neural networks generated from hESCs by electrophysiological studies: \r\nElectrophysiological recordings will be performed using neural tissues generated from hESCs and laid down onto MEAs. Spontaneous as well as evoked field potentials will be recorded in control nervous tissues and after exposure of the neuro-glial networks to reference pharmacological molecules to verify that the nervous tissues are responding similarly to primary neural tissues.\r\nDeliverable: Report on the 3D neural tissue electrophysiological characterization. 01.01.2013\r\n31.06.2013\r\nAcute neurotoxicity studies: \r\nAcute dose-responses of neurotoxicants will be performed in 3D human neural networks to assess their effects on the neuronal activity in vitro by means of electrophysiological M.E.A. recordings. \r\nDeliverable: Report on the 3D neural tissue electrophysiological characterization for reference neurotoxic compounds. 01.07.2013\r\n31.12.2013\r\nGene expression profile in 3D neural tissues: \rGene expression profile: We will verify gene expression toxicity signatures using different types of xenobiotics (control and known to induce adverse effects on neural tissues). Human neuro-glial networks will be treated acutely or repeatedly with different concentrations of a series of different types of neurotoxicants. mRNA will be isolated at different culture time points and measured by RT-qPCR. \r\nDeliverable: Report on the 3D neural tissue gene profile of specific markers in control and using reference neurotoxic molecules. 01.04.2013\r\n31.12.2013\r\nProteomic analyses of 3D human neural tissues: \r\nThe proteomic analysis profile will be performed in control conditions and after treatment of 3 D human neural tissues with reference neurotoxic molecules.\r\nDeliverable: Report on proteomic neurotoxic profile of 3D human neural tissues. 01.03.2013\r\n31.12.2013\r\nFunctional activities of 2D neural networks using calcium mobilization assay: \r\nMeasurement of calcium mobilization: Variations in the concentration of intracellular calcium, which is known to trigger a number of events including the release of synaptic transmitter, will be measured using Fluo-4 Flexstation Calcium assay kit. Human neuronal cells will be grown in 96 well plates to fit to the workflow system. Reference toxic molecules will be tested to validate the approach.\r\nDeliverable: Report on the validation of the Calcium mobilization as a functional assay to assess neurotoxicity. 01.03.2013\r\n31.12.2013\r\nFunctional activities of 2D neural networks using Neurotransmitter Transporter Uptake Assay: \r\nHomogeneous Neurotransmitter Transporter Uptake Assay: The assay includes a fluorescent indicator dye that mimics the neurotransmitters serotonin, norepinephrine, and dopamine which are actively transported into the cells via the specific neurotransmitter transporters. The fluorescent substrate that mimics the biogenic amine neurotransmitters is then taken up into the cell through those specific transporters, resulting in increased intracellular fluorescence intensity. This homogeneous, fluorescent assay is robust, sensitive, and specific, an","value":"340000.00","finished":true,"pilier":6,"url":null,"keywords":null,"disciplines":[],"axes":[],"partners":[],"collaborators":[{"id":7786581,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"dominiqu.trinchan","project":36062},{"id":7786582,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"laetitia.nikles","project":36062},{"id":7786583,"role":"ME","display":true,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"adrien.roux","project":36062},{"id":7786584,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"herve.sthioul","project":36062},{"id":7786585,"role":"RP","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"luc.stoppini","project":36062}],"dataHub":true,"startAt":"2013-01-01T00:00:00+01:00","endAt":"2014-06-30T00:00:00+02:00","fundingSource":"hepia inSTI; Universit\u00e9 de Gen\u00e8ve; hepia inSTI","publications":[],"projectUrl":null,"repo_name":null}}

{"id":7781901,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"dominiqu.trinchan","project":{"translations":{"fr":{"id":20565,"title":"LTA 2023.","description":"Hepia et Unige unissent leurs efforts afin de cr\u00e9er le Laboratoire de Technologie Avanc\u00e9e, ci-apr\u00e8s LTA, une infrastructure con\u00e7ue pour valoriser le savoir-faire et les \u00e9quipements de pointe de l'Universit\u00e9 de Gen\u00e8ve et de la HES-SO Gen\u00e8ve aupr\u00e8s des industries. Porte d'entr\u00e9e vers pr\u00e8s de 20 groupes de recherche et plus de 100 \u00e9quipements et savoir-faire, le LTA apporte des solutions techniques originales aux petites, moyennes et grandes entreprises.\r\n\r\nObjectifs :\r\n\r\nPar la cr\u00e9ation du LTA, . Hepia et Unige entendent :\r\na) proposer des mandats de prestations et mettre \u00e0 disposition des initiatives individuelles (acad\u00e9miques ou industrielles) des comp\u00e9tences et des technologies de haut niveau pr\u00e9sentes aupr\u00e8s des hautes \u00e9coles susmentionn\u00e9es ;\r\nb) valoriser les laboratoires existants et rendre tout nouvel investissement efficient ;\r\nc) offrir un guichet unique aux entreprises et leur facilit\u00e9 l'acc\u00e8s aux \u00e9quipements et aux  groupes de recherche.\r\n"},"en":{"id":20566,"title":"LTA 2023.","description":"Hepia et Unige unissent leurs efforts afin de cr\u00e9er le Laboratoire de Technologie Avanc\u00e9e, ci-apr\u00e8s LTA, une infrastructure con\u00e7ue pour valoriser le savoir-faire et les \u00e9quipements de pointe de l'Universit\u00e9 de Gen\u00e8ve et de la HES-SO Gen\u00e8ve aupr\u00e8s des industries. Porte d'entr\u00e9e vers pr\u00e8s de 20 groupes de recherche et plus de 100 \u00e9quipements et savoir-faire, le LTA apporte des solutions techniques originales aux petites, moyennes et grandes entreprises.\r\n\r\nObjectifs :\r\n\r\nPar la cr\u00e9ation du LTA, . Hepia et Unige entendent :\r\na) proposer des mandats de prestations et mettre \u00e0 disposition des initiatives individuelles (acad\u00e9miques ou industrielles) des comp\u00e9tences et des technologies de haut niveau pr\u00e9sentes aupr\u00e8s des hautes \u00e9coles susmentionn\u00e9es ;\r\nb) valoriser les laboratoires existants et rendre tout nouvel investissement efficient ;\r\nc) offrir un guichet unique aux entreprises et leur facilit\u00e9 l'acc\u00e8s aux \u00e9quipements et aux  groupes de recherche.\r\n"},"de":{"id":20567,"title":"LTA 2023.","description":"Hepia et Unige unissent leurs efforts afin de cr\u00e9er le Laboratoire de Technologie Avanc\u00e9e, ci-apr\u00e8s LTA, une infrastructure con\u00e7ue pour valoriser le savoir-faire et les \u00e9quipements de pointe de l'Universit\u00e9 de Gen\u00e8ve et de la HES-SO Gen\u00e8ve aupr\u00e8s des industries. Porte d'entr\u00e9e vers pr\u00e8s de 20 groupes de recherche et plus de 100 \u00e9quipements et savoir-faire, le LTA apporte des solutions techniques originales aux petites, moyennes et grandes entreprises.\r\n\r\nObjectifs :\r\n\r\nPar la cr\u00e9ation du LTA, . Hepia et Unige entendent :\r\na) proposer des mandats de prestations et mettre \u00e0 disposition des initiatives individuelles (acad\u00e9miques ou industrielles) des comp\u00e9tences et des technologies de haut niveau pr\u00e9sentes aupr\u00e8s des hautes \u00e9coles susmentionn\u00e9es ;\r\nb) valoriser les laboratoires existants et rendre tout nouvel investissement efficient ;\r\nc) offrir un guichet unique aux entreprises et leur facilit\u00e9 l'acc\u00e8s aux \u00e9quipements et aux  groupes de recherche.\r\n"}},"id":123374,"acronym":"LTA_2023","mainTitle":"LTA 2023.","mainDescription":"Hepia et Unige unissent leurs efforts afin de cr\u00e9er le Laboratoire de Technologie Avanc\u00e9e, ci-apr\u00e8s LTA, une infrastructure con\u00e7ue pour valoriser le savoir-faire et les \u00e9quipements de pointe de l'Universit\u00e9 de Gen\u00e8ve et de la HES-SO Gen\u00e8ve aupr\u00e8s des industries. Porte d'entr\u00e9e vers pr\u00e8s de 20 groupes de recherche et plus de 100 \u00e9quipements et savoir-faire, le LTA apporte des solutions techniques originales aux petites, moyennes et grandes entreprises.\r\n\r\nObjectifs :\r\n\r\nPar la cr\u00e9ation du LTA, . 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{"id":7780211,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"dominiqu.trinchan","project":{"translations":{"fr":{"id":23245,"title":"Outils de coupe ultraperformants en cermets structur\u00e9s par laser \u00e0 impulsions ultra-courtes.","description":"Because of their outstanding properties, Nickel-based superalloys and Titanium-based alloys are frequently used in aerospace and biomedical applications. Among these properties one can notable mention high specific strength, high temperature resistance, creep resistance, wear resistance. In addition, Ti alloys exhibit biocompatibility. Moreover Ni-Ti alloys can exhibit superelastic behaviour. Unfortunately their excellent mechanical properties make their machining very difficult and expensive. The cutting tool represents a key element in chip removal machining. In order to increase performance (speed, throughput, accuracy, life expectancy) and decrease machining energy, several important properties are required: \r\n1) Very hard and tough materials. \r\n2) Maintenance of hardness at high temperature.\r\n3) Optimal tribology to reduce chip adhesion on the cutting edge of the tool and facilitate chip evacuation.\r\n4) Edges with very sharp angles capable of machining fine details by micromachining.\r\n\r\nAt present, the basic material for cutting tool insert is mainly tungsten carbide -cobalt (WC-Co), also called 'hard metal' or cemented carbide. Although very hard, these inserts are often coated with PVD coatings to increase their performance. Typical coatings (TiN, TiAlN, TiSiN...) have hardness of about 2000-3000 HV. The hardest material is diamond, but it is still very expensive to deposit as DLC (diamond like carbon coating), and is only used for the machining of complex materials (e.g. composites) and for precision machining.\r\nCermets (titanium carbon-nitride-based) offer enhanced properties but their high hardness makes it particularly difficult to create sharp edges by \"classic\" grinding. \r\nThe aim of this project is to develop a cutting tool production method based on:\r\n        - The production of cermets with optimal properties by pressing and sintering \r\n        - Replacement of edge grinding by LASER (cold) machining.\r\n        - The deposition of ultra-hard tribological coatings by HIPIMS sputtering (High Power Impulse Magnetron Sputtering).\r\nConcerning cermet manufacturing : The uniaxial pressing of the powders in an electric press, followed by sintering offers an economical and sustainable way. The composition (carbonitrides, carbides, metallic binders and additives) must be adjusted, the debinding and sintering parameters optimised to ensure good density and mechanical properties.\r\nConcerning ultra-short impulse LASER machining: Conventional grinding generates high mechanical forces and high thermal impact that can cause micro-cracks, thus limiting tool life. The use of the picosecond laser allows \"cold\" ablation without thermal or mechanical impact and to create micro-structures, therefore very sharp edges (without rounding caused by grinding).\r\nConcerning coatings made by HIPIMS: find optimal deposition conditions in order to obtain very hard (~ 2000-3000 HV) and tribological coatings. TiSiN based coatings seem to be the most appropriate for this application due to their good mechanical properties and ease of implementation, allowing greater control of deposit parameters.\r\nThe performance of the processed tools will be evaluated through comparative machining tests, cutting force and tool life measurements. The expected impact of this project on simple tools (turning inserts) is to draw the attention of manufacturers to mixed technologies in order to subsequently study more complex tools, such as milling bits in the framework of an Innosuisse project.\r\n"},"en":{"id":23246,"title":"Outils de coupe ultraperformants en cermets structur\u00e9s par laser \u00e0 impulsions ultra-courtes.","description":"Because of their outstanding properties, Nickel-based superalloys and Titanium-based alloys are frequently used in aerospace and biomedical applications. Among these properties one can notable mention high specific strength, high temperature resistance, creep resistance, wear resistance. In addition, Ti alloys exhibit biocompatibility. Moreover Ni-Ti alloys can exhibit superelastic behaviour. Unfortunately their excellent mechanical properties make their machining very difficult and expensive. The cutting tool represents a key element in chip removal machining. In order to increase performance (speed, throughput, accuracy, life expectancy) and decrease machining energy, several important properties are required: \r\n1) Very hard and tough materials. \r\n2) Maintenance of hardness at high temperature.\r\n3) Optimal tribology to reduce chip adhesion on the cutting edge of the tool and facilitate chip evacuation.\r\n4) Edges with very sharp angles capable of machining fine details by micromachining.\r\n\r\nAt present, the basic material for cutting tool insert is mainly tungsten carbide -cobalt (WC-Co), also called 'hard metal' or cemented carbide. Although very hard, these inserts are often coated with PVD coatings to increase their performance. Typical coatings (TiN, TiAlN, TiSiN...) have hardness of about 2000-3000 HV. The hardest material is diamond, but it is still very expensive to deposit as DLC (diamond like carbon coating), and is only used for the machining of complex materials (e.g. composites) and for precision machining.\r\nCermets (titanium carbon-nitride-based) offer enhanced properties but their high hardness makes it particularly difficult to create sharp edges by \"classic\" grinding. \r\nThe aim of this project is to develop a cutting tool production method based on:\r\n        - The production of cermets with optimal properties by pressing and sintering \r\n        - Replacement of edge grinding by LASER (cold) machining.\r\n        - The deposition of ultra-hard tribological coatings by HIPIMS sputtering (High Power Impulse Magnetron Sputtering).\r\nConcerning cermet manufacturing : The uniaxial pressing of the powders in an electric press, followed by sintering offers an economical and sustainable way. The composition (carbonitrides, carbides, metallic binders and additives) must be adjusted, the debinding and sintering parameters optimised to ensure good density and mechanical properties.\r\nConcerning ultra-short impulse LASER machining: Conventional grinding generates high mechanical forces and high thermal impact that can cause micro-cracks, thus limiting tool life. The use of the picosecond laser allows \"cold\" ablation without thermal or mechanical impact and to create micro-structures, therefore very sharp edges (without rounding caused by grinding).\r\nConcerning coatings made by HIPIMS: find optimal deposition conditions in order to obtain very hard (~ 2000-3000 HV) and tribological coatings. TiSiN based coatings seem to be the most appropriate for this application due to their good mechanical properties and ease of implementation, allowing greater control of deposit parameters.\r\nThe performance of the processed tools will be evaluated through comparative machining tests, cutting force and tool life measurements. The expected impact of this project on simple tools (turning inserts) is to draw the attention of manufacturers to mixed technologies in order to subsequently study more complex tools, such as milling bits in the framework of an Innosuisse project.\r\n"},"de":{"id":23247,"title":"Outils de coupe ultraperformants en cermets structur\u00e9s par laser \u00e0 impulsions ultra-courtes.","description":"Because of their outstanding properties, Nickel-based superalloys and Titanium-based alloys are frequently used in aerospace and biomedical applications. Among these properties one can notable mention high specific strength, high temperature resistance, creep resistance, wear resistance. In addition, Ti alloys exhibit biocompatibility. Moreover Ni-Ti alloys can exhibit superelastic behaviour. Unfortunately their excellent mechanical properties make their machining very difficult and expensive. The cutting tool represents a key element in chip removal machining. In order to increase performance (speed, throughput, accuracy, life expectancy) and decrease machining energy, several important properties are required: \r\n1) Very hard and tough materials. \r\n2) Maintenance of hardness at high temperature.\r\n3) Optimal tribology to reduce chip adhesion on the cutting edge of the tool and facilitate chip evacuation.\r\n4) Edges with very sharp angles capable of machining fine details by micromachining.\r\n\r\nAt present, the basic material for cutting tool insert is mainly tungsten carbide -cobalt (WC-Co), also called 'hard metal' or cemented carbide. Although very hard, these inserts are often coated with PVD coatings to increase their performance. Typical coatings (TiN, TiAlN, TiSiN...) have hardness of about 2000-3000 HV. The hardest material is diamond, but it is still very expensive to deposit as DLC (diamond like carbon coating), and is only used for the machining of complex materials (e.g. composites) and for precision machining.\r\nCermets (titanium carbon-nitride-based) offer enhanced properties but their high hardness makes it particularly difficult to create sharp edges by \"classic\" grinding. \r\nThe aim of this project is to develop a cutting tool production method based on:\r\n        - The production of cermets with optimal properties by pressing and sintering \r\n        - Replacement of edge grinding by LASER (cold) machining.\r\n        - The deposition of ultra-hard tribological coatings by HIPIMS sputtering (High Power Impulse Magnetron Sputtering).\r\nConcerning cermet manufacturing : The uniaxial pressing of the powders in an electric press, followed by sintering offers an economical and sustainable way. The composition (carbonitrides, carbides, metallic binders and additives) must be adjusted, the debinding and sintering parameters optimised to ensure good density and mechanical properties.\r\nConcerning ultra-short impulse LASER machining: Conventional grinding generates high mechanical forces and high thermal impact that can cause micro-cracks, thus limiting tool life. The use of the picosecond laser allows \"cold\" ablation without thermal or mechanical impact and to create micro-structures, therefore very sharp edges (without rounding caused by grinding).\r\nConcerning coatings made by HIPIMS: find optimal deposition conditions in order to obtain very hard (~ 2000-3000 HV) and tribological coatings. TiSiN based coatings seem to be the most appropriate for this application due to their good mechanical properties and ease of implementation, allowing greater control of deposit parameters.\r\nThe performance of the processed tools will be evaluated through comparative machining tests, cutting force and tool life measurements. The expected impact of this project on simple tools (turning inserts) is to draw the attention of manufacturers to mixed technologies in order to subsequently study more complex tools, such as milling bits in the framework of an Innosuisse project.\r\n"}},"id":125971,"acronym":"VAL_P2 - CoCeCu","mainTitle":"Outils de coupe ultraperformants en cermets structur\u00e9s par laser \u00e0 impulsions ultra-courtes.","mainDescription":"Because of their outstanding properties, Nickel-based superalloys and Titanium-based alloys are frequently used in aerospace and biomedical applications. Among these properties one can notable mention high specific strength, high temperature resistance, creep resistance, wear resistance. In addition, Ti alloys exhibit biocompatibility. Moreover Ni-Ti alloys can exhibit superelastic behaviour. Unfortunately their excellent mechanical properties make their machining very difficult and expensive. The cutting tool represents a key element in chip removal machining. In order to increase performance (speed, throughput, accuracy, life expectancy) and decrease machining energy, several important properties are required: \r\n1) Very hard and tough materials. \r\n2) Maintenance of hardness at high temperature.\r\n3) Optimal tribology to reduce chip adhesion on the cutting edge of the tool and facilitate chip evacuation.\r\n4) Edges with very sharp angles capable of machining fine details by micromachining.\r\n\r\nAt present, the basic material for cutting tool insert is mainly tungsten carbide -cobalt (WC-Co), also called 'hard metal' or cemented carbide. Although very hard, these inserts are often coated with PVD coatings to increase their performance. Typical coatings (TiN, TiAlN, TiSiN...) have hardness of about 2000-3000 HV. The hardest material is diamond, but it is still very expensive to deposit as DLC (diamond like carbon coating), and is only used for the machining of complex materials (e.g. composites) and for precision machining.\r\nCermets (titanium carbon-nitride-based) offer enhanced properties but their high hardness makes it particularly difficult to create sharp edges by \"classic\" grinding. \r\nThe aim of this project is to develop a cutting tool production method based on:\r\n        - The production of cermets with optimal properties by pressing and sintering \r\n        - Replacement of edge grinding by LASER (cold) machining.\r\n        - The deposition of ultra-hard tribological coatings by HIPIMS sputtering (High Power Impulse Magnetron Sputtering).\r\nConcerning cermet manufacturing : The uniaxial pressing of the powders in an electric press, followed by sintering offers an economical and sustainable way. The composition (carbonitrides, carbides, metallic binders and additives) must be adjusted, the debinding and sintering parameters optimised to ensure good density and mechanical properties.\r\nConcerning ultra-short impulse LASER machining: Conventional grinding generates high mechanical forces and high thermal impact that can cause micro-cracks, thus limiting tool life. The use of the picosecond laser allows \"cold\" ablation without thermal or mechanical impact and to create micro-structures, therefore very sharp edges (without rounding caused by grinding).\r\nConcerning coatings made by HIPIMS: find optimal deposition conditions in order to obtain very hard (~ 2000-3000 HV) and tribological coatings. TiSiN based coatings seem to be the most appropriate for this application due to their good mechanical properties and ease of implementation, allowing greater control of deposit parameters.\r\nThe performance of the processed tools will be evaluated through comparative machining tests, cutting force and tool life measurements. The expected impact of this project on simple tools (turning inserts) is to draw the attention of manufacturers to mixed technologies in order to subsequently study more complex tools, such as milling bits in the framework of an Innosuisse project.\r\n","value":"12000.00","finished":true,"pilier":6,"url":null,"keywords":null,"disciplines":[],"axes":[],"partners":[{"id":1840875,"name":"","confidential":false,"types":[{"id":4,"code":"CO"}],"institution":"VS - Institut Syst\u00e8mes industriels","class":"academique"},{"id":1840876,"name":"","confidential":false,"types":[{"id":3,"code":"RP"},{"id":4,"code":"CO"}],"institution":"hepia inSTI","class":"academique"},{"id":1840877,"name":"","confidential":false,"types":[{"id":4,"code":"CO"}],"institution":"Ing\u00e9nierie des surfaces","class":"academique"}],"collaborators":[{"id":7780211,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"dominiqu.trinchan","project":125971},{"id":7780212,"role":"RP","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"georg.walder","project":125971},{"id":7780213,"role":"CO","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"efrain.carrenom","project":125971},{"id":7780214,"role":"CO","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"raymond.constant","project":125971}],"dataHub":true,"startAt":"2023-04-18T00:00:00+02:00","endAt":"2023-10-31T00:00:00+01:00","fundingSource":"HES-SO Rectorat","publications":[],"projectUrl":null,"repo_name":null}}

{"id":7775189,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"dominiqu.trinchan","project":{"translations":{"fr":{"id":18545,"title":"LTA 2022.","description":"Hepia et Unige unissent leurs efforts afin de cr\u00e9er le Laboratoire de Technologie Avanc\u00e9e, ci-apr\u00e8s LTA, une infrastructure con\u00e7ue pour valoriser le savoir-faire et les \u00e9quipements de pointe de l'Universit\u00e9 de Gen\u00e8ve et de la HES-SO Gen\u00e8ve aupr\u00e8s des industries. Porte d'entr\u00e9e vers pr\u00e8s de 20 groupes de recherche et plus de 100 \u00e9quipements et savoir-faire, le LTA apporte des solutions techniques originales aux petites, moyennes et grandes entreprises.\r\n\r\nObjectifs :\r\n\r\nPar la cr\u00e9ation du LTA, . Hepia et Unige entendent :\r\na) proposer des mandats de prestations et mettre \u00e0 disposition des initiatives individuelles (acad\u00e9miques ou industrielles) des comp\u00e9tences et des technologies de haut niveau pr\u00e9sentes aupr\u00e8s des hautes \u00e9coles susmentionn\u00e9es ;\r\nb) valoriser les laboratoires existants et rendre tout nouvel investissement efficient ;\r\nc) offrir un guichet unique aux entreprises et leur facilit\u00e9 l'acc\u00e8s aux \u00e9quipements et aux  groupes de recherche.\r\n"},"en":{"id":18546,"title":"LTA 2022.","description":"Hepia et Unige unissent leurs efforts afin de cr\u00e9er le Laboratoire de Technologie Avanc\u00e9e, ci-apr\u00e8s LTA, une infrastructure con\u00e7ue pour valoriser le savoir-faire et les \u00e9quipements de pointe de l'Universit\u00e9 de Gen\u00e8ve et de la HES-SO Gen\u00e8ve aupr\u00e8s des industries. Porte d'entr\u00e9e vers pr\u00e8s de 20 groupes de recherche et plus de 100 \u00e9quipements et savoir-faire, le LTA apporte des solutions techniques originales aux petites, moyennes et grandes entreprises.\r\n\r\nObjectifs :\r\n\r\nPar la cr\u00e9ation du LTA, . Hepia et Unige entendent :\r\na) proposer des mandats de prestations et mettre \u00e0 disposition des initiatives individuelles (acad\u00e9miques ou industrielles) des comp\u00e9tences et des technologies de haut niveau pr\u00e9sentes aupr\u00e8s des hautes \u00e9coles susmentionn\u00e9es ;\r\nb) valoriser les laboratoires existants et rendre tout nouvel investissement efficient ;\r\nc) offrir un guichet unique aux entreprises et leur facilit\u00e9 l'acc\u00e8s aux \u00e9quipements et aux  groupes de recherche.\r\n"},"de":{"id":18547,"title":"LTA 2022.","description":"Hepia et Unige unissent leurs efforts afin de cr\u00e9er le Laboratoire de Technologie Avanc\u00e9e, ci-apr\u00e8s LTA, une infrastructure con\u00e7ue pour valoriser le savoir-faire et les \u00e9quipements de pointe de l'Universit\u00e9 de Gen\u00e8ve et de la HES-SO Gen\u00e8ve aupr\u00e8s des industries. Porte d'entr\u00e9e vers pr\u00e8s de 20 groupes de recherche et plus de 100 \u00e9quipements et savoir-faire, le LTA apporte des solutions techniques originales aux petites, moyennes et grandes entreprises.\r\n\r\nObjectifs :\r\n\r\nPar la cr\u00e9ation du LTA, . Hepia et Unige entendent :\r\na) proposer des mandats de prestations et mettre \u00e0 disposition des initiatives individuelles (acad\u00e9miques ou industrielles) des comp\u00e9tences et des technologies de haut niveau pr\u00e9sentes aupr\u00e8s des hautes \u00e9coles susmentionn\u00e9es ;\r\nb) valoriser les laboratoires existants et rendre tout nouvel investissement efficient ;\r\nc) offrir un guichet unique aux entreprises et leur facilit\u00e9 l'acc\u00e8s aux \u00e9quipements et aux  groupes de recherche.\r\n"}},"id":115618,"acronym":"LTA_2022","mainTitle":"LTA 2022.","mainDescription":"Hepia et Unige unissent leurs efforts afin de cr\u00e9er le Laboratoire de Technologie Avanc\u00e9e, ci-apr\u00e8s LTA, une infrastructure con\u00e7ue pour valoriser le savoir-faire et les \u00e9quipements de pointe de l'Universit\u00e9 de Gen\u00e8ve et de la HES-SO Gen\u00e8ve aupr\u00e8s des industries. Porte d'entr\u00e9e vers pr\u00e8s de 20 groupes de recherche et plus de 100 \u00e9quipements et savoir-faire, le LTA apporte des solutions techniques originales aux petites, moyennes et grandes entreprises.\r\n\r\nObjectifs :\r\n\r\nPar la cr\u00e9ation du LTA, . Hepia et Unige entendent :\r\na) proposer des mandats de prestations et mettre \u00e0 disposition des initiatives individuelles (acad\u00e9miques ou industrielles) des comp\u00e9tences et des technologies de haut niveau pr\u00e9sentes aupr\u00e8s des hautes \u00e9coles susmentionn\u00e9es ;\r\nb) valoriser les laboratoires existants et rendre tout nouvel investissement efficient ;\r\nc) offrir un guichet unique aux entreprises et leur facilit\u00e9 l'acc\u00e8s aux \u00e9quipements et aux  groupes de recherche.\r\n","value":null,"finished":true,"pilier":5,"url":null,"keywords":null,"disciplines":[],"axes":[],"partners":[{"id":1839529,"name":"","confidential":false,"types":[{"id":3,"code":"RP"},{"id":4,"code":"CO"}],"institution":"hepia inSTI","class":"academique"}],"collaborators":[{"id":7775189,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"dominiqu.trinchan","project":115618},{"id":7775190,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"malek.fedel","project":115618},{"id":7775191,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"herve.sthioul","project":115618},{"id":7775192,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"martina.zselysch","project":115618},{"id":7775193,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"gilles.triscone","project":115618},{"id":7775194,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"hugo.corcelle","project":115618},{"id":7775195,"role":"RP","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"nicolas.stucki","project":115618}],"dataHub":true,"startAt":"2022-01-01T00:00:00+01:00","endAt":"2023-06-30T00:00:00+02:00","fundingSource":"Universit\u00e9 de Gen\u00e8ve","publications":[],"projectUrl":null,"repo_name":null}}

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Hepia et Unige entendent :\r\na) proposer des mandats de prestations et mettre \u00e0 disposition des initiatives individuelles (acad\u00e9miques ou industrielles) des comp\u00e9tences et des technologies de haut niveau pr\u00e9sentes aupr\u00e8s des hautes \u00e9coles susmentionn\u00e9es ;\r\nb) valoriser les laboratoires existants et rendre tout nouvel investissement efficient ;\r\nc) offrir un guichet unique aux entreprises et leur facilit\u00e9 l'acc\u00e8s aux \u00e9quipements et aux  groupes de recherche.\r\n"},"de":{"id":22798,"title":"LTA 2024.","description":"Hepia et Unige unissent leurs efforts afin de cr\u00e9er le Laboratoire de Technologie Avanc\u00e9e, ci-apr\u00e8s LTA, une infrastructure con\u00e7ue pour valoriser le savoir-faire et les \u00e9quipements de pointe de l'Universit\u00e9 de Gen\u00e8ve et de la HES-SO Gen\u00e8ve aupr\u00e8s des industries. 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The final objective is to settle a general health formula based on a specific mix with honeys and lyophilized flowers, gathered in one product an highly rich micro-biodiversity, with healthful profile.  This basic formula may come under different ranges of products as capsules, cosmetics, syrups, lozenges.\r\n"},"en":{"id":14299,"title":"Flower Microbiome Research Program 2020-2021. \r\n","description":"The objective of this research program is to highly valorize the powers of flowers in a right understanding of its overall properties, including its amazing pro-biotic and pre-biotic properties. The program shall deal with fresh flowers or lyophilized flowers, which are free from any radiations or treatments susceptible to damage the microflora. It should try to assess the microbial diversity and its different profiles in reputed flowers, in honeys and bee hives derived products; they would be compared with ordinary flowers and honeys, or flowers grown in a poor environment quality, and with industrial honey. The final objective is to settle a general health formula based on a specific mix with honeys and lyophilized flowers, gathered in one product an highly rich micro-biodiversity, with healthful profile.  This basic formula may come under different ranges of products as capsules, cosmetics, syrups, lozenges.\r\n"},"de":{"id":14300,"title":"Flower Microbiome Research Program 2020-2021. \r\n","description":"The objective of this research program is to highly valorize the powers of flowers in a right understanding of its overall properties, including its amazing pro-biotic and pre-biotic properties. 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The final objective is to settle a general health formula based on a specific mix with honeys and lyophilized flowers, gathered in one product an highly rich micro-biodiversity, with healthful profile.  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{"id":7761582,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"dominiqu.trinchan","project":{"translations":{"fr":{"id":11332,"title":"LTA 2019.","description":"Hepia et Unige unissent leurs efforts afin de cr\u00e9er le Laboratoire de Technologie Avanc\u00e9e, ci-apr\u00e8s LTA, une infrastructure con\u00e7ue pour valoriser le savoir-faire et les \u00e9quipements de pointe de l'Universit\u00e9 de Gen\u00e8ve et de la HES-SO Gen\u00e8ve aupr\u00e8s des industries. Porte d'entr\u00e9e vers pr\u00e8s de 20 groupes de recherche et plus de 100 \u00e9quipements et savoir-faire, le LTA apporte des solutions techniques originales aux petites, moyennes et grandes entreprises.\r\n\r\nObjectifs :\r\n\r\nPar la cr\u00e9ation du LTA, . 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Hepia et Unige entendent :\r\na) proposer des mandats de prestations et mettre \u00e0 disposition des initiatives individuelles (acad\u00e9miques ou industrielles) des comp\u00e9tences et des technologies de haut niveau pr\u00e9sentes aupr\u00e8s des hautes \u00e9coles susmentionn\u00e9es ;\r\nb) valoriser les laboratoires existants et rendre tout nouvel investissement efficient ;\r\nc) offrir un guichet unique aux entreprises et leur facilit\u00e9 l'acc\u00e8s aux \u00e9quipements et aux  groupes de recherche.\r\n"},"de":{"id":11334,"title":"LTA 2019.","description":"Hepia et Unige unissent leurs efforts afin de cr\u00e9er le Laboratoire de Technologie Avanc\u00e9e, ci-apr\u00e8s LTA, une infrastructure con\u00e7ue pour valoriser le savoir-faire et les \u00e9quipements de pointe de l'Universit\u00e9 de Gen\u00e8ve et de la HES-SO Gen\u00e8ve aupr\u00e8s des industries. 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Or, avec les changements environnementaux, l'utilisation de certains pesticides et la fragmentation des habitats par l'urbanisation, les pollinisateurs et plus particuli\u00e8rement les abeilles sont en danger. Face au d\u00e9clin important des populations d'abeilles, des campagnes de promotion des pollinisateurs en milieu urbain ont vu le jour.  En effet, de plus en plus de ruches sont install\u00e9es en milieu urbain ainsi que des espaces de prairies fleuries afin d'assurer une meilleure survie des pollinisateurs.\r\nToutefois, plusieurs questions demeurent, car \u00e0 ce jour, il n'existe pas d'information pr\u00e9cise sur ce sujet pour le canton de Gen\u00e8ve et la Suisse romande. Quelles strat\u00e9gies adopter pour favoriser les abeilles en ville afin qu'elles jouent pleinement leur r\u00f4le de pollinisatrices ? Est-ce que les ressources florales en zone urbanis\u00e9e sont suffisantes et adapt\u00e9es \u00e0 leurs besoins ? Ces informations sont pourtant cruciales afin d'int\u00e9grer la question des abeilles mellif\u00e8res (Apis mellifera), dans une approche d'am\u00e9nagement et de verdissement des espaces urbains du canton de Gen\u00e8ve, mais \u00e9galement celle de la protection des autres pollinisateurs telles que les nombreuses esp\u00e8ces d'abeilles sauvages.\r\nLe pr\u00e9sent projet aborde deux aspects : celui des abeilles domestiques (Apis mellifera) et celui des abeilles sauvages (nombreuses esp\u00e8ces d'abeilles solitaires et bourdons). Il vise tout d'abord \u00e0 : 1) \u00e9valuer le potentiel du canton de Gen\u00e8ve \u00e0 h\u00e9berger des ruches en milieu urbanis\u00e9, 2) d\u00e9terminer les ressources exploit\u00e9es par les abeilles domestiques par la r\u00e9alisation d'un suivi des ruches existantes en milieu urbain et en les comparant \u00e0 des ruches des milieux p\u00e9ri-urbain et rural, 3) \u00e9valuer si les ressources en nectar et en pollen sont suffisantes en milieu urbain pour assurer la p\u00e9rennit\u00e9 de tous les hym\u00e9nopt\u00e8res pollinisateurs et 4) tester diff\u00e9rentes strat\u00e9gies de v\u00e9g\u00e9talisation et d'entretien des espaces verts dans le but de favoriser au mieux ces pollinisateurs.\"\r\n","value":"360274.41","finished":true,"pilier":6,"url":null,"keywords":null,"disciplines":[],"axes":[],"partners":[],"collaborators":[{"id":7756237,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"dominiqu.trinchan","project":58551},{"id":7756238,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"natacha.guillaum","project":58551},{"id":7756239,"role":"RP","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"sophie.rochefor","project":58551},{"id":7756240,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"charlene.heiniger","project":58551},{"id":7756241,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"jane.orourke","project":58551},{"id":7756242,"role":"ME","display":true,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"patrice.prunier","project":58551},{"id":7756243,"role":"ME","display":false,"displayRole":true,"displayFinancialPartner":true,"displayAcademicPartner":true,"displayProfessionalPartner":true,"collaborator":"ewa.renaud","project":58551}],"dataHub":true,"startAt":"2016-03-01T00:00:00+01:00","endAt":"2021-12-31T00:00:00+01:00","fundingSource":"Fondation Wilsdorf; hepia inTNE; Fondation Gelbert; hepia inTNE","publications":[],"projectUrl":null,"repo_name":null}}

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